JAK/STAT revisited

JAK
In previous posts, we discussed about the role of the kinome in the development of cancer. We will focus today on the JAK/STAT pathway.

The JAK-STAT signaling pathway is one of the most extensively studied signal transduction pathways, involving four Janus kinases (JAKs) (JAK1, JAK2, JAK3, and TYK2) and seven signal transducers and activators of transcription (STATs) (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6). [Read more…]

Focus on the JAK-STAT pathway…

The Janus kinase (JAK) / Signal Transducer and Activator of Transcription (STAT) pathway a key regulator of cellular proliferation, differentiation, migration, apoptosis and survival. Numerous cytokines, growth factors and Interferons interact with the JAK/STAT signaling pathway which in turn   regulates many biological processes, especially in hematopoietic development and immune responses.

[Read more…]