Neuroregenerative effects of microtubule stabilizing Epothilone B

Epothilone B is a bioactive microtubule-stabilizing small molecule. This blood-brain barrier permeable coumpound belongs to the most popular potent cytoskeletal modeling molecules for in vitro cell based assays (see the previous post dedicated to “5 Cytoskeletal Modeling Molecules“).Epothilone B structure cat. nr 10-2133 Focus Biomolecules tebu-bio
Recently, Ruschel J. et al. have demonstrated that its delayed systemic administration in rodents promoted axonal regeneration with Central Nervous System (CNS) injuries. These findings open new therapeutic areas regarding the use of microtubule-stabilizing drug compounds, like Epothilones, in CNS recovery and neuroregeneration. [Read more…]

Postdoc Position at the Dundee University

Dundee University logoA post-doctoral position is available in Pr. Tomo Tanaka’s lab (Centre for Gene Regulation and Expression – University of Dundee), for up to three years, to study the mechanisms of chromosome segregation in vivo like the in vitro kinetochore–microtubule interaction using TIRF microscopy (Job Reference: LS0530). The closing date is Saturday, January 31, 2015.

To know more about this opportunity, please look at the dedicated web page or visit Pr. Tomo Tanaka’s web site.

You might also look at the latest vacancies at the College of Life Sciences of the University of Dundee!

2 new Actin and Tubulin live-cell imaging stains – without transfection!

Cytoskeletal live-cell imaging is extremely powerful when investigating cellular processes such as cytokinesis, motility and organelle transport and organization. The current experimental procedures remain nevertheless cumbersome and long. This post demonstrates how cell permeable, transfection free, Tubulin and Actin red fluorescent dyes help Cell biologists in analysing cytoskeleton dynamics in living cells.

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How to probe motor-domains of kinesins?

In the past, molecular motor proteins like kinesins have been investigated with macromolecular approaches. Recent research on kinesins has been focused on resolving how kinesin is regulated by intramolecular dynamics. [Read more…]