Discovery of functional serum biomarkers

Lung cancer is one of the most common malignancies, and the leading cause of cancer-related fatality. Current diagnostic practices for common cancers rely heavily on imaging technologies. These methods are quite accurate, but still have a probability of having false-positive findings. Also, there is a substantial need for non-invasive ways to test whether the nodules are benign or malignant.

Blood-based biomarkers have potential in cancer screening, and their role could extend further from general population risk assessment to treatment response evaluation and recurrence monitoring. However, despite much research effort, biomarkers able to predict disease onset and evolution are not always easy to find, or distinctive enough. [Read more…]

Functional Proteomics for biomarker characterisation

Discovery of biomarkers has advanced significantly in the past few years due to the new developments in Genomics, Proteomics, Metabolomics and other systematic approaches. However, one area of systematic biological analysis that is still relatively underserved is the rapid elucidation of the biological functions of a proteome.
Let’s take a step back. Proteins are present in the cell, but they also have a function. Therefore, in some instances, the mere identification of the presence of a protein may not be enough to elucidate the biological pathways involved in a given disease. It is for this that activity assays are needed.

[Read more…]