Basics about insulin and dedicated research tools

Diabetes is a major health concern. And its research can be a nightmare sometimes. tebu-bio strive to offer a comprehensive range of research tools and services to study Obesity, Diabetes, and Metabolic syndrome (including pancreatic islet cells), and tools to unravel signaling mechanisms in insulin secretion. Anyhow, it might be good, though, to go back to the basics from time to time. Let’s remember our graduate courses (more or less years ago) about Insulin and its biological roles.

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Focus on apolipoproteins

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Role of apolipoproteins in different diseases.

Apolipoproteins, with amphipathic properties, form lipoprotein particles with phospholipids and transport hydrophobic lipids through lymphatic and blood circulations to designated peripheral tissues or organs for energy supply, biomolecule synthesis, or degradation. Off-balance of apolipoproteins has been implicated in numerous diseases such as SLE, myocardial infarction, Alzheimer’s, and diabetes. Apolipoproteins emerge as risk markers to pinpoint different diseases.

For Cardiovascular diseases, apoF and apoB seem to have a predominant role. [Read more…]

5 key criteria for selecting the most appropriate ELISA kit to detect Human Cardiotrophin-1

Cardiotrophin-1 Factor

Cardiotrophin-1 (CT-1) is a cardiac hypertrophic factor with cardiac myocyte protective properties. CT-1 belongs to the interleukin-6 cytokine family and acts through LIF receptor ß/glycoprotein 130 (gp130)-coupled signaling pathways.

CT-1 intracellular signaling pathways enlist kinases (ERK, MAP, JAK) but also STAT and PI3-kinase/Akt systems.

Cardiac CT-1 expression is increased by hypoxia, where it protects cardiac myocytes from ischemic injury and apoptosis.

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