Get your ELISA results before lunch!

ELISAs are widely used in biomarker-related studies, especially when a high number of samples is involved, and only a few biomarkers need to be quantified. That said, incubations can be somehow cumbersome, and some days one would like to get results fast (and accurate), and this is not always possible. [Read more…]

Don’t miss any neurotrophin!

Neurotrophins are important biomarkers in Neurobiology, including stem cell development to neural lineages. BDNF and NGF are the ones being studied in most cases. However, it has been found that neurotrophins do not act independently. Many publications have described the coordinated actions of 2 or more neurotrophins, especially in development, but also in the adult. [Read more…]

Specific cytokines & growth factors in… neurobiology!

Neurobiology is the study of cells of the nervous system and their organization into functional circuits that process information and mediate behavior.

[Read more…]

Unlimited sources of neural cells mimicking CNS disorders for in vitro bioassays

Access to neural cellular models for in vitro Neuroscience research enters into a new era.

XCell Science, experts in cellular and genome engineering, provide genetically modified cellular models differentiated from Human induced Pluripotent Stem Cell (iPSC) lines. tebu-bio bring its scientific and logistics skills to deliver in Europe these high-quality and characterized neural cell derivatives for R&D, drug discovery, toxicology and regenerative medicine approaches.

Unlimited sources of biologically relevant functional neural cells

Proprietary high-efficiency protocols allow the directed differentiation of these iPS lines into a variety of functional neural cells, such as:A large collection of neural cells (XCell Science - tebu-bio)

  • Neural Stem Cells (NSC),
  • Neurons,
  • Dopaminergic neurons,
  • Astrocytes.

Disease-specific knock-out isogenic neural cell lines

tebu-bio’s experts are pleased to introduce a collection of isogenic knock-out iPSC lines mimicking genetic defects identified in CNS disorders (Parkinson’s and Alzheimer’s diseases, Autism, Schizophrenia and Amyotrophic Lateral Sclerosis (ALS)):

  • BDNF-/-: Homozygous knockout of the BDNF gene,

    Dopa Neural Cells (XCell Science by tebu-bio)

    Expression of TH in Ready-to-use XCell DOPA cells prolonged cultured in DOPA medium.

  • APOE-/-: Homozygous knockout of the APOE gene,
  • DISC1-/-: Homozygous knockout of the DISC1 gene,
  • CNTNAP2-/-: Homozygous knockout of the CNTNAP2 gene,
  • SOD1-/-: Homozygous knockout of the SOD1 gene,
  • Park2-/-: Homozygous knockout of the Park2 gene,
  • Park7-/-: Homozygous knockout of the Park7 gene.

Want to know more about these unlimited iPSC-derived neural cellular models ?

XCell Science logo by tebu-bio

XCell Science by tebu-bio

 

Be among the first to receive the XCell Science launch pack by tebu-bio to optimise your in vitro CNS-specific cellular models.

Sign up now!

 

iPSC-derived Neural cells characterization - XCell Science by tebu-bio

iPSC-derived Neural cells characterization – XCell Science by tebu-bio

Related posts regarding CNS and Stem cell studies:

 

Exogenous tissue Plasminogen Activator administration increases Hippocampal mature BDNF Levels by Rodier M. et al.

In this study, the authors investigated the effect of exogenous tissue Plasminogen Activator (tPA) administration on brain levels of pro- and mature Brain-Derived Neurotrophic Factor (BDNF) in rats.
They have shown that t-PA induced a rise in mature BDNF expression and subsequent TrkB receptor activation probably via the N-Methyl-D-Aspartate (NMDA)-Receptors activation rather than through increase in plasmin activity.

Congratulations to the authors, who turned to tebu-bio’s range of products when selecting their discovery tools to measure Plasmin and t-PA activities with Fluorescent Activity Assays (SensoLyte Rh 110 Plasmin and SensoLyte AMC t-PA respectively).

Want to know more?

Source: Rodier M. et al. “Exogenous t-PA Administration Increases Hippocampal Mature BDNF Levels. Plasmin- or NMDA-Dependent Mechanism?” (2014) PLoS ONE 9(3): e92416. doi:10.1371/journal.pone.0092416

Related research products regarding Plasmin and tPA.