Innovative solutions in cosmetology: Cosmetic 360

The world’s leading perfumery cosmetics network, Cosmetic Valley, announces that its 2015 Cosmetic-360 Meeting will take place in Paris (October 15 – 16th, 2015).tebu-bio belong to the Cosmetic Valley Network.jpg

As a member of this network, tebu-bio will be participating in this trade show which is focussed on open innovations this year.

Recent advances in R&D in vitro cosmetic testings

Several innovative solutions have been designed by tebu-bio laboratories to better understand the mechanisms of action of ingredients, and also to further characterize efficient compounds.

These solutions cover cell-based and functional assays but also gene expression analysis.

Cell culture platform

Starting with cell culture, tebu-bio benefits from a huge bank of primary human cells (including keratinocytes, fibroblasts, adipocytes, sebocytes…) from various sources (donors with a large range of choice ex. gender, age, type, body zones) to develop tailored experimental projects.

Cosmetic-360, Paris 2015As an example, using keratinocytes from young vs. aged donors gives the opportunity to identify biomarkers involved in senescence and by comparison with those present in young donors, determine pathway and efficiency of active compounds. These projects do not need any artificial aging tools like UV irradiation which can generate pathway specific aging process and are not always representative of all natural mechanisms involved. Another approach uses adipocytes issued from normal or high BMI donors, which are helpful tools for testing all slimming mechanisms, including the adipokine pathway.

In combination with oxygen controlled cell culture devices, tebu-bio offers a wide variety of cell culture models including strict physioxic cell conditions for more predictive results and by modifying oxygen concentration they are able to create oxydative stress assays as well as hypoxic stress environment.

Profiling approaches

After cell culture treatment, tebu-bio’s labs offer unique access to a wide variety of biomarker identification tools (from cell culture supernatants for soluble released signaling biomarkers or intracellular biomarkers impacting cell behaviour). Approaches are multiple to allow high versatility such as :

  • Pathway specific gene profiling arrays (oxydative stress, senescence, innate immunity, inflammation, cell metabolism etc…)
  • Protein profiling arrays for qualitative (like multiple Western Blots with up to 1,350 markers per array) or quantitative (like multiple ELISAs with up to 360 markers at once) approaches. Markers available are soluble ones which will impact cell environment or intracellular ones wich will modify internal cell behaviour.
  • miRNA profiling – highly promising biomarkers are either secreted and found in cell culture supernatant or remain intracellular. miRNAs have the capacity to down regulate RNA translation and are thus powerful mediators of cell activity.

Bioassays

To further complete the analysis of active compounds, functional bioassays are ideal and available as ready-to-use kits or as fee-for-services. The most popular ones include:

Come and meet us at Cosmetic 360 – get your free invitation

I will be pleased to meet you at Cosmetic 360 and discuss the recent advances in cosmetology and in R&D. To receive an invitation to Cosmetic 360 free-of-charge offered by tebu-bio, get in contact via the form below. The number of complimentary inviations available is limited, early application is advised.

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