Focus on the JAK-STAT pathway…

The Janus kinase (JAK) / Signal Transducer and Activator of Transcription (STAT) pathway a key regulator of cellular proliferation, differentiation, migration, apoptosis and survival. Numerous cytokines, growth factors and Interferons interact with the JAK/STAT signaling pathway which in turn   regulates many biological processes, especially in hematopoietic development and immune responses.

The signaling is initiated upon the binding of cytokines (like Cardiotrophin-1, IFNs, LIF, TGF, EGF, bFGF…) to their cognate receptors causing receptor dimerization  and trans-phosphorylation of the recruited JAKs. Once activated, JAKs phophorylate the STAT family members. These p-STATs in turn translocate to the nucleus and act as dimers to regulate the expression of target genes acting as transcription factors.

Dysregulation of JAK-STAT signaling leads to several immune disorders, such as hyperlgE syndrome, erythremia, and leukemia.

 

 

JAK-STAT Pathway

A selection of 100% guaranteed research antibodies related to the JAK-STAT pathway

STAT4-antibody_IHC-P_GTX50403-1

STAT4 antibody

GTX101955_39750_IFA

Looking for a specific intracellular cell signaling pathway?

We strive to provide you regularly with new and updated pathways to support you in your research. If you are looking for a specific pathway, don’t hesitate to contact us.

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