Focus on the Autophagy pathway…

Autophagy is the process of “self-cannibalization” of cellular proteins or organelles through lysosomal degradation. This process plays a critical role in cellular homeostasis by scavenging macromolecules in response to nutrient deprivation and by facilitating the removal of misfolded protein aggregates. It is alse a biological process aiming at recycling cytoplasmic organelles and other constituents by delivering them to the lysosome for degradation.

Autophagy and apoptosis also interact through a complex network of cross-talk to regulate cell death. Autophagy has been implicated in many different diseases, including neurodegeneration, cardiac and autoimmune diseases and cancers.
The role of autophagy in cancer is complex and paradoxical. While autophagic deficiency has been shown to promote tumorigenesis in animal models, autophagy may actually support tumor growth by enhancing cancer cell survival in the face of nutrient depletion or accumulation of toxic molecules.

Autophagy pathway

A selection of 100% guaranteed research antibodies related to the autophagy pathway

  • Anti mTOR: a rabbit polyclonal antibody to mTOR
  • Anti LC3: a rabbit polyclonal antibody to LC3 (microtubule-associated protein 1 light chain 3 alpha)
  • Anti p53: a mouse monoclonal antibody to human p53  
  • Anti Beclin 1: a rabbit polyclonal antibody to Beclin 1 (beclin 1, autophagy related)
  • Anti BCL2: a mouse monoclonal antibody to BCL2 (B-cell CLL/lymphoma 2)

To explore even further, here’s a selection of autophagy related primary antibodies…

Looking for a specific intracellular pathway?

We strive to provide you regularly with new and updated pathways to support you in your research. If you are looking for a specific pathway, don’t hesitate to contact us.

Trackbacks

  1. […] of ubiquitin chains, regardless of the linkage, can form polyubiquitin fibrils to initiate the Autophagy pathway. A deficiency of the autophagy causes cytotoxic accumulation of ubiquitin-positive aggregates […]

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