Exogenous tissue Plasminogen Activator administration increases Hippocampal mature BDNF Levels by Rodier M. et al.

In this study, the authors investigated the effect of exogenous tissue Plasminogen Activator (tPA) administration on brain levels of pro- and mature Brain-Derived Neurotrophic Factor (BDNF) in rats.
They have shown that t-PA induced a rise in mature BDNF expression and subsequent TrkB receptor activation probably via the N-Methyl-D-Aspartate (NMDA)-Receptors activation rather than through increase in plasmin activity.

Congratulations to the authors, who turned to tebu-bio’s range of products when selecting their discovery tools to measure Plasmin and t-PA activities with Fluorescent Activity Assays (SensoLyte Rh 110 Plasmin and SensoLyte AMC t-PA respectively).

Want to know more?

Source: Rodier M. et al. “Exogenous t-PA Administration Increases Hippocampal Mature BDNF Levels. Plasmin- or NMDA-Dependent Mechanism?” (2014) PLoS ONE 9(3): e92416. doi:10.1371/journal.pone.0092416

Related research products regarding Plasmin and tPA.

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