Monoclonal antibody (mAb) engineering and their development as therapeutic or diagnostic tools have become the must in pharmaceutical industry, in medical biotech and in the research world. Purification of this type of biosimilar requires a particular know-how.
Because of their rapid growth and their affordability, bacterial expression systems are very convenient when producing recombinant proteins.
Nevertheless, one of the key elements in the design of the experimental procedures for producing a recombinant protein in E. Coli is the selection of the right bacterial strain for the right protein. This is not an easy step but remains of utmost importance.
Based on our in-house experience, we’ve compiled a guide aimed at helping you in your choice of the “ideal” engineered bacterial strain for efficient recombinant proteins expression.
You’ll find useful information for selecting the reliable strains suited to your downstream applications, with characteristics (quality, biological activity, folding…).
Interested? Download your copy here:
Guide to choosing the best bacterial strains for recombinant protein expression
Many recombinant proteins (rec. proteins) are now commercially available. And many of them, mainly secreted soluble proteins, are biologically active, so there shouldn’t be any need to look for alternatives such as custom productions.
So the question is, why should you prefer a special production?
Well, there are several reasons (and they’re good ones too!). [Read more…]