ATRA is a well known for its ability to regulate cell differentiation. However, retinoids are excellent chromophores and efficiently absorb light and isomerise. This is not necessarily a feature required of cell culture reagents, where consistency and reliability of a product is important for robust reproducible results.
To address this issue, Reinnervate have recently developed ec23® as a pan-RAR receptor agonist that is stable, but maintains the same biological activity as ATRA. [Read more…]
Following our series of posts on tumour immunity, I’d like to mention an article published by researchers from the Ben-Gurion University of the Negev (Israel). The authors investigated the negative correlation between caffeine consumption and incidence of tumours. Or to say it more simply, intake of caffeine favours the immune system fighting tumours. (1) [Read more…]
A recent publication by ArrayBridge, Inc., in cooperation with Wayne State University, focuses on monoclonal antibody (mAb) Higher Order Structure Analysis.
The clinical and biological properties of protein-based therapeutics, or biologics, are closely related to their Higher Order Structures (HOS), which in turn can be altered by many physical and chemical conditions. The paper describes a novel technology to monitor changes in mAb HOS – the Protein Conformational Array (PCA) ELISA – which is based on a unique bank of more than 30 well-characterized antibodies enabling the measurement of protein epitope change on the surface of the mAb. [Read more…]
PSA (Prostate Specific Antigen) has been (and still is) the biomarker of choice for the diagnosis and follow up of patients having a Prostate Cancer (PCa). However, even if it has been used for quite some time now, it is not too specific and its levels may be high for other physiological situations, and not only cancer. Therefore, the need for more specific biomarkers for the correct management of PCa patients is mandatory. A recent publication by Heidegger et al. suggests that Eotaxin-1 (CCL11) could be a more specific biomarker. [Read more…]
The outcome of the interaction between Mycobacterium tuberculosis (Mtb) and a macrophage depends on the interplay between host defense and bacterial immune subversion mechanisms. MicroRNAs (miRNAs) critically regulate several host defense pathways, but their role in the Mtb-macrophage interplay remains unclear.
Be patient, Valentine’s day will soon be here to brighten the winter season…
To count down the days leading up to Sunday Feb. 14th, why don’t you try your luck with tebu-bio’s new Facebook game ?
You might win some chocolates… the real thing, not virtual ones !
tebu-bio is pleased to announce their agreement with Time Bioscience to distribute their innovative products in the Wnt/ß catenin research field throughout Europe
tebu-bio (Le Perray, France) has signed an agreement with Time Bioscience to bring European researchers access to Time Bioscience’s Wnt/ß catenin related portfolio through their network of local offices in 9 countries.
Time Bioscience (Worcester, MA, USA) offers a rapidly growing portfolio of drug discovery platforms, consisting of high quality proteins involved in the Wnt/catenin pathway and reporter cell lines designed to monitor the activity of β-catenin-based Wnt signal transduction pathway.
Dr. Tom Shi (CEO) who has a strong background in drug discovery research targeting Wnt signaling pathway, says “We are excited to collaborate with tebu-bio on the marketing our products throughout the European research community, especially as we believe that tebu-bio has a very good standing in the Drug Discovery field and that our products will accelerate Drug Discovery related campaigns targeting the Wnt/ß catenin pathway.”
Dr. Ali El Bayâ (tebu-bio, Sales Manager – Proteins & Protein based Products & Services) adds “We at tebu-bio are constantly seeking to complement our offer linked to drug screening activities, as well as fundamental research in the Academic environment. Both in Drug Discovery and in basic research the Wnt/ß catenin pathway is a hot topic, and we are happy to expand our global offer in this exciting field.”
To find out more about Time Bioscience’s products available from tebu-bio, visit tebu-bio’s website.
About Time Bioscience
Time Bioscience, based in Worcester, MA, USA, produces and markets Wnt/ß catenin related products. The focus lays on highly active proteins involved in this pathway like Wnt variants, Wnt signaling inhibitors, and Wnt signaling receptors, as well as reporter cell lines and their control cell lines which enable scientists to measure the effects of Wnt and the potential of compounds to inhibit these effects. Compound Screening Kits designed to allow investigators to quickly identify novel inhibitors of Dkk2-LRP6 interaction are under development.
tebu-bio is a pan-European company with 9 local offices throughout Europe, specialised in providing innovative reagents and laboratory services in Life Sciences. tebu-bio’s own laboratories operating in France provide researchers with an ever-growing offer of standard or custom lab services.
tebu-bio is an active member of recognised professional networks and clusters (Medicen, Cosmetic Valley…), and received the PM’up award in the Health/Life Sciences sector, attributed to dynamic, high-potential companies by the “Région Ile-de-France” (regional French government). tebu-bio regularly signs new European distribution agreements, proof of the company’s dynamism and professional drive. More information on tebu-bio’s website.
The year 2015 was full of significant publications in the field of ophthalmology. Here’s a snapshot of 2 “proof-of-concept” studies suggesting that “Sterols” could be promising approaches to treat cataract.
Winter is coming. It’s getting colder, days are getting shorter… and Christmas might still seem a long way off (or maybe not long enough if you still have shopping to do!).
Fortunately, our Advent Calendar is here to bring some light and festive happiness to your day ! Scratch a window every day in December on tebu-bio’s virtual Advent Calendar and you might win some chocolates.
And… in good tradition, on Christmas Eve there will be a big box for the final happy winner!