Mitochondria keep cells “healthy” in their environment. In this post, we’ll take a look at a new fluorescent assay for the monitoring of mitophagy, a process aimed at clearing damaged or superfluous mitochondria by autophagy, in mammalian cells.
Renal injury can sometimes be induced by drugs. Some examples of renal damage-inducing drugs include some widespread treatments, such as ß-Lactam antibiotics, bisphosphonates, non-steroidal anti-inflammatory drugs, diuretics, aminoglycoside antibiotics, antineoplastic agents and radiocontrast agents.
Since 2008, both the FDA and the EMEA indicated that additional tests may be necessary to assess new drug safety and prevent from renal toxicity. Though these recommendations are voluntary, many pharmaceutical companies have started gathering data on nephrotoxicity biomarkers. [Read more…]
Small molecules known to modulate biological activies of the K-Ras oncogene are predominantly of synthetic origin (ex. Salirasib). Nevetheless, various publications have recently demontrated the biological potential of microbial metabolites in KRAS studies. Here’s a good opportunity to briefly review a few of these compounds.
NanoSurface ANFS offer biomimetic architecture, of which the benefits are:
- Align mechanically sensitive cells
- Phenotypic maturation induced
- Promote cells adhesion, migration & proliferation
- more mature, more physiologic!
Interested in learning more?
Read all about this technology in a previous post here.
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Breaking news for cancer researchers! We are pleased to have recently added innovative cancer Arrays to our product offer. You might tell me that there are a lot of new cancer arrays every year and it’s not really necessary to write a post about it… but read on and I’m sure you’ll share my enthusiasm!
Good news for the interferon domain this week with the launch of a new kit: the Verikine Human Interferon Gamma Receptor 1 (IFNGR1) ELISA Kit. This immunoassay provides researchers with a high quality product and excellent data reproducibility for this area.
The role of the interactions between tumor cells and their microenvironment (TME) is now well-established in various stages of cancer development. Cytokines, produced by both the cancer and the immune cells, actively contribute to these critical connections (see the previous posts related to the crosstalk between cancer and immune cells in relation to tumor escape, immunoediting and immunosurveillance).
In a recent review published in BBA, RayBiotech‘s team highlights the “cytokine signatures and dynamics” seen during cancer development. They also demonstrate the necessity of designing relevant multiplex immunoassays for the profiling and the quantification of cytokines in biomarker and anti-cancer drug discovery programs.
Valerie Sloane Jones, Ren-Yu Huang, Li-Pai Chen, Zhe-Sheng Chen, Liwu Fu, Ruo-Pan Huang “Cytokines in cancer drug resistance: Cues to new therapeutic strategies” (2016) Biochimica et Biophysica Acta, Volume 1865, Issue 2, 255–265. DOI:10.1016/j.bbcan.2016.03.005.
Download the publication written by RayBiotech, the leader in planar Antibody Arrays.