The Wnt cell signalling pathway is a high-potential therapeutical target in cancer research. It’s deeply linked to cellular fate through modulating cell proliferation, mobility, interaction, and polarity. Wnt is not only a key player in the embryonic development but also in the homeostasis, and remodeling of adult tissues (heart, bone, neural tube, angiogenesis…) via somatic stem cell modulations and stem cell self-renewal. Abnormal Wnt signaling events are seen in various types of human carcinomas and in a variety of other cancer types.
Like other important cell signaling pathways (ex. PI3K/Akt/mTOR, Notch…), the Wnt pathway involves numerous partners and intracellular cascades of events. The “Wnt” acronym was first described in the 1990’s after the identification of 2 homologous genes found in Drosophilia (Wingless wg) and in Mouse (Int-1) a few years before.
Wnt/ß-Catenin pathway – a brief overview
Get started down the Wnt/ß-Catenin pathway with this overview, which takes a look at:
- The non canonical ß-Catenin independant planar cell polarity pathway (Wnt/PCP or Wnt/JNK)
- The non canonical ß-Catenin independant Wnt/calcium pathway (Wnt/Ca2+)
- The canonical ß-Catenin dependant pathway (Wnt/ß-Catenin)
What are the new promising therapeutical candidates? Which new or existing research tools are popular to further analyse this pathway?
This guide is aimed at bringing a global overview of this fascinating Wnt / ß-Catenin signalling pathway but also introducing 4 innovative ways to decipher Wnt/ß-catenin pathway in research and drug discovery programs.