This is the conclusion of Liu X. et al. who demonstrated, in a mouse model, that RhoA/ROCK signaling pathway modulates insulin secretion of 3D cultured islet pancreatic ß-cells. This modulation is made through the regulation of Connexin 36.
External links regarding RhoA/ROCK in insulin secretion of pancreatic ß-cells
- Liu X. et al. “Involvement of RhoA/ROCK in insulin secretion of pancreatic ß-cells in 3D
culture” (2014) Cell Tissue Res. DOI: 10.1007/s00441-014-1961-2
- Cell permeable C3 transferase (cat. nr CT04), inhibits cellular Rho within 2-4h
- Selective Rho Kinase (ROCK) inhibitors and anti Human RhoA antibody (a Mouse monoclonal that only recognizes RhoA, not RhoB, RhoC, Rac1, Rac2, Rac3, Cdc42 or H-Ras).
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